USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P08581 USC-OGP 2-DE database:  P08581 P08581 General information about the entry View entry in simple text format Entry name MET_HUMAN Primary accession number P08581 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Hepatocyte growth factor receptor; Short=HGF receptor; EC=2.7.10.1; AltName: Full=HGF/SF receptor; AltName: Full=Proto-oncogene c-Met; AltName: Full=Scatter factor receptor; Short=SF receptor; AltName: Full=Tyrosine-protein kinase Met; Flags: Precursor;. Gene name Name=MET Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0263: pI=5.64; Mw=147363 Cross-references UniProtKB/Swiss-Prot P08581; MET_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name MET_HUMAN Primary accession number P08581 Secondary accession number(s) A1L467 B5A932 E7EQ94 O60366 Q12875 Q9UDX7 Q9UPL8 Sequence was last modified on  July 7, 2009 (version 4) Annotations were last modified on  March 15, 2017 (version 225) Name and origin of the protein Description RecName: Full=Hepatocyte growth factor receptor; Short=HGF receptor; EC=2.7.10.1; AltName: Full=HGF/SF receptor; AltName: Full=Proto-oncogene c-Met; AltName: Full=Scatter factor receptor; Short=SF receptor; AltName: Full=Tyrosine-protein kinase Met; Flags: Precursor; Gene name Name=MET Encoded on Name=MET Keywords 3D-structure; Alternative splicing; ATP-binding; Chromosomal rearrangement; Complete proteome; Deafness; Disease mutation; Disulfide bond; Glycoprotein; Kinase; Membrane; Non-syndromic deafness; Nucleotide-binding; Phosphoprotein; Polymorphism; Proto-oncogene; Receptor; Reference proteome; Repeat; Secreted; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J02958; AAA59591.1; -; mRNA EMBL X54559; CAB56793.1; -; mRNA EMBL EU826570; ACF47606.1; -; mRNA EMBL AC002080; AAB54047.1; -; Genomic_DNA EMBL AC002543; AAC60383.1; -; Genomic_DNA EMBL AC004416; AAF66137.2; -; Genomic_DNA EMBL CH236947; EAL24359.1; -; Genomic_DNA EMBL CH471070; EAW83509.1; -; Genomic_DNA EMBL BC130420; AAI30421.1; -; mRNA EMBL U08818; AAB60323.1; ALT_SEQ; mRNA EMBL M35074; AAA59590.1; -; mRNA CCDS CCDS43636.1; -. [P08581-1]; . CCDS CCDS47689.1; -. [P08581-2]; . PIR A40175; TVHUME; . RefSeq NP_000236.2; NM_000245.3. [P08581-1]; . RefSeq NP_001120972.1; NM_001127500.2. [P08581-2]; . UniGene Hs.132966; -; . PDB 1FYR; X-ray; 2.40 A; I/J/K/L=1356-1359 PDB 1R0P; X-ray; 1.80 A; A=1049-1360 PDB 1R1W; X-ray; 1.80 A; A=1049-1360 PDB 1SHY; X-ray; 3.22 A; B=25-567 PDB 1SSL; NMR; -; A=519-562 PDB 1UX3; Model; -; A=25-656 PDB 2G15; X-ray; 2.15 A; A=1038-1346 PDB 2RFN; X-ray; 2.50 A; A/B=1048-1351 PDB 2RFS; X-ray; 2.20 A; A=1048-1351 PDB 2UZX; X-ray; 2.80 A; B/D=25-740 PDB 2UZY; X-ray; 4.00 A; B/D=25-740 PDB 2WD1; X-ray; 2.00 A; A=1055-1346 PDB 2WGJ; X-ray; 2.00 A; A=1051-1348 PDB 2WKM; X-ray; 2.20 A; A=1051-1348 PDB 3A4P; X-ray; 2.54 A; A=1049-1360 PDB 3BUX; X-ray; 1.35 A; A/C=997-1009 PDB 3C1X; X-ray; 2.17 A; A=1049-1360 PDB 3CCN; X-ray; 1.90 A; A=1048-1350 PDB 3CD8; X-ray; 2.00 A; A=1048-1350 PDB 3CE3; X-ray; 2.40 A; A=1049-1360 PDB 3CTH; X-ray; 2.30 A; A=1049-1360 PDB 3CTJ; X-ray; 2.50 A; A=1049-1360 PDB 3DKC; X-ray; 1.52 A; A=1049-1360 PDB 3DKF; X-ray; 1.80 A; A=1049-1360 PDB 3DKG; X-ray; 1.91 A; A=1049-1360 PDB 3EFJ; X-ray; 2.60 A; A/B=1048-1351 PDB 3EFK; X-ray; 2.20 A; A/B=1048-1351 PDB 3F66; X-ray; 1.40 A; A/B=1052-1349 PDB 3F82; X-ray; 2.50 A; A=1049-1360 PDB 3I5N; X-ray; 2.00 A; A=1048-1350 PDB 3L8V; X-ray; 2.40 A; A=1049-1360 PDB 3LQ8; X-ray; 2.02 A; A=1051-1348 PDB 3Q6U; X-ray; 1.60 A; A=1048-1348 PDB 3Q6W; X-ray; 1.75 A; A=1048-1348 PDB 3QTI; X-ray; 2.00 A; A/B=1050-1360 PDB 3R7O; X-ray; 2.30 A; A=1048-1348 PDB 3RHK; X-ray; 1.94 A; A/B=1038-1346 PDB 3U6H; X-ray; 2.00 A; A=1048-1351 PDB 3U6I; X-ray; 2.10 A; A=1048-1351 PDB 3VW8; X-ray; 2.10 A; A=1024-1352 PDB 3ZBX; X-ray; 2.20 A; A=1051-1348 PDB 3ZC5; X-ray; 2.20 A; A=1051-1348 PDB 3ZCL; X-ray; 1.40 A; A=1051-1348 PDB 3ZXZ; X-ray; 1.80 A; A=1051-1348 PDB 3ZZE; X-ray; 1.87 A; A=1051-1348 PDB 4AOI; X-ray; 1.90 A; A=1051-1348 PDB 4AP7; X-ray; 1.80 A; A=1051-1348 PDB 4DEG; X-ray; 2.00 A; A=1048-1351 PDB 4DEH; X-ray; 2.00 A; A=1048-1351 PDB 4DEI; X-ray; 2.05 A; A=1048-1351 PDB 4EEV; X-ray; 1.80 A; A=1038-1346 PDB 4GG5; X-ray; 2.42 A; A=1038-1346 PDB 4GG7; X-ray; 2.27 A; A=1038-1346 PDB 4IWD; X-ray; 1.99 A; A=1048-1348 PDB 4K3J; X-ray; 2.80 A; B=39-564 PDB 4KNB; X-ray; 2.40 A; A/B/C/D=1060-1346 PDB 4MXC; X-ray; 1.63 A; A=1038-1346 PDB 4O3T; X-ray; 2.99 A; B=25-567 PDB 4O3U; X-ray; 3.04 A; B=25-567 PDB 4R1V; X-ray; 1.20 A; A=1055-1345 PDB 4R1Y; X-ray; 2.00 A; A=1055-1346 PDB 4XMO; X-ray; 1.75 A; A=1048-1350 PDB 4XYF; X-ray; 1.85 A; A=1048-1351 PDB 5DG5; X-ray; 2.60 A; A/B=1038-1346 PDB 5EOB; X-ray; 1.75 A; A=1038-1346 PDB 5EYC; X-ray; 1.80 A; A=1048-1351 PDB 5EYD; X-ray; 1.85 A; A=1048-1351 PDB 5HLW; X-ray; 1.97 A; A=1057-1355 PDB 5HNI; X-ray; 1.71 A; X/Y=1049-1360 PDB 5HO6; X-ray; 1.97 A; A=1049-1360 PDB 5HOA; X-ray; 2.14 A; A=1049-1360 PDB 5HOR; X-ray; 2.20 A; A=1049-1360 PDB 5HTI; X-ray; 1.66 A; A=1038-1346 PDB 5T3Q; X-ray; 2.00 A; A=1048-1350 PDBsum 1FYR; -; . PDBsum 1R0P; -; . PDBsum 1R1W; -; . PDBsum 1SHY; -; . PDBsum 1SSL; -; . PDBsum 1UX3; -; . PDBsum 2G15; -; . PDBsum 2RFN; -; . PDBsum 2RFS; -; . PDBsum 2UZX; -; . PDBsum 2UZY; -; . PDBsum 2WD1; -; . PDBsum 2WGJ; -; . PDBsum 2WKM; -; . PDBsum 3A4P; -; . PDBsum 3BUX; -; . PDBsum 3C1X; -; . PDBsum 3CCN; -; . PDBsum 3CD8; -; . PDBsum 3CE3; -; . PDBsum 3CTH; -; . PDBsum 3CTJ; -; . PDBsum 3DKC; -; . PDBsum 3DKF; -; . PDBsum 3DKG; -; . PDBsum 3EFJ; -; . PDBsum 3EFK; -; . PDBsum 3F66; -; . PDBsum 3F82; -; . PDBsum 3I5N; -; . PDBsum 3L8V; -; . PDBsum 3LQ8; -; . PDBsum 3Q6U; -; . PDBsum 3Q6W; -; . PDBsum 3QTI; -; . PDBsum 3R7O; -; . PDBsum 3RHK; -; . PDBsum 3U6H; -; . PDBsum 3U6I; -; . PDBsum 3VW8; -; . PDBsum 3ZBX; -; . PDBsum 3ZC5; -; . PDBsum 3ZCL; -; . PDBsum 3ZXZ; -; . PDBsum 3ZZE; -; . PDBsum 4AOI; -; . PDBsum 4AP7; -; . PDBsum 4DEG; -; . PDBsum 4DEH; -; . PDBsum 4DEI; -; . PDBsum 4EEV; -; . PDBsum 4GG5; -; . PDBsum 4GG7; -; . PDBsum 4IWD; -; . PDBsum 4K3J; -; . PDBsum 4KNB; -; . PDBsum 4MXC; -; . PDBsum 4O3T; -; . PDBsum 4O3U; -; . PDBsum 4R1V; -; . PDBsum 4R1Y; -; . PDBsum 4XMO; -; . PDBsum 4XYF; -; . PDBsum 5DG5; -; . PDBsum 5EOB; -; . PDBsum 5EYC; -; . PDBsum 5EYD; -; . PDBsum 5HLW; -; . PDBsum 5HNI; -; . PDBsum 5HO6; -; . PDBsum 5HOA; -; . PDBsum 5HOR; -; . PDBsum 5HTI; -; . PDBsum 5T3Q; -; . ProteinModelPortal P08581; -; . SMR P08581; -; . BioGrid 110391; 39; . DIP DIP-6023N; -; . IntAct P08581; 87; . MINT MINT-4837114; -; . STRING 9606.ENSP00000317272; -; . BindingDB P08581; -; . ChEMBL CHEMBL3717; -; . DrugBank DB07969; 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol; . DrugBank DB08875; Cabozantinib; . DrugBank DB08865; Crizotinib; . DrugBank DB02152; K-252a; . DrugBank DB05216; MP470; . DrugBank DB06995; N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide; . DrugBank DB05153; XL184; . GuidetoPHARMACOLOGY 1815; -; . iPTMnet P08581; -; . PhosphoSitePlus P08581; -; . SwissPalm P08581; -; . UniCarbKB P08581; -; . BioMuta MET; -; . DMDM 251757497; -; . OGP P08581; -; . EPD P08581; -; . MaxQB P08581; -; . PaxDb P08581; -; . PeptideAtlas P08581; -; . PRIDE P08581; -; . DNASU 4233; -; . Ensembl ENST00000318493; ENSP00000317272; ENSG00000105976. [P08581-2]; . Ensembl ENST00000397752; ENSP00000380860; ENSG00000105976. [P08581-1]; . Ensembl ENST00000436117; ENSP00000410980; ENSG00000105976. [P08581-3]; . GeneID 4233; -; . KEGG hsa:4233; -; . UCSC uc003vij.4; human. [P08581-1]; . CTD 4233; -; . DisGeNET 4233; -; . GeneCards MET; -; . HGNC HGNC:7029; MET; . HPA CAB005282; -; . HPA CAB018577; -; . HPA HPA055607; -; . MalaCards MET; -; . MIM 114550; phenotype; . MIM 164860; gene; . MIM 605074; phenotype; . MIM 607278; phenotype; . MIM 616705; phenotype; . neXtProt NX_P08581; -; . OpenTargets ENSG00000105976; -; . Orphanet 106; Autism; . Orphanet 47044; Familial papillary renal cell carcinoma; . PharmGKB PA30763; -; . eggNOG KOG1095; Eukaryota; . eggNOG KOG3610; Eukaryota; . eggNOG COG0515; LUCA; . GeneTree ENSGT00810000125384; -; . HOGENOM HOG000220900; -; . HOVERGEN HBG006348; -; . InParanoid P08581; -; . KO K05099; -; . OMA QRVDLFM; -; . PhylomeDB P08581; -; . TreeFam TF317402; -; . BRENDA 2.7.10.1; 2681; . Reactome R-HSA-1257604; PIP3 activates AKT signaling; . Reactome R-HSA-2219530; Constitutive Signaling by Aberrant PI3K in Cancer; . Reactome R-HSA-416550; Sema4D mediated inhibition of cell attachment and migration; . Reactome R-HSA-5673001; RAF/MAP kinase cascade; . Reactome R-HSA-6806942; MET Receptor Activation; . Reactome R-HSA-6807004; Negative regulation of MET activity; . Reactome R-HSA-6811558; PI5P; PP2A and IER3 Regulate PI3K/AKT Signaling; . Reactome R-HSA-8851805; MET activates RAS signaling; . Reactome R-HSA-8851907; MET activates PI3K/AKT signaling; . Reactome R-HSA-8865999; MET activates PTPN11; . Reactome R-HSA-8874081; MET activates PTK2 signaling; . Reactome R-HSA-8875360; InlB-mediated entry of Listeria monocytogenes into host cell; . Reactome R-HSA-8875513; MET interacts with TNS proteins; . Reactome R-HSA-8875555; MET activates RAP1 and RAC1; . Reactome R-HSA-8875656; MET receptor recycling; . Reactome R-HSA-8875791; MET activates STAT3; . SignaLink P08581; -; . SIGNOR P08581; -; . ChiTaRS MET; human; . EvolutionaryTrace P08581; -; . GeneWiki C-Met; -; . GenomeRNAi 4233; -; . PRO PR:P08581; -; . Proteomes UP000005640; Chromosome 7; . Bgee ENSG00000105976; -; . CleanEx HS_MET; -; . ExpressionAtlas P08581; baseline and differential; . Genevisible P08581; HS; . GO GO:0009925; C:basal plasma membrane; IDA:MGI; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell; . GO GO:0016021; C:integral component of membrane; NAS:UniProtKB; . GO GO:0005887; C:integral component of plasma membrane; TAS:ProtInc; . GO GO:0005622; C:intracellular; IEA:GOC; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0005008; F:hepatocyte growth factor-activated receptor activity; TAS:ProtInc; . GO GO:0046934; F:phosphatidylinositol-4; 5-bisphosphate 3-kinase activity; TAS:Reactome GO GO:0019903; F:protein phosphatase binding; IPI:UniProtKB; . GO GO:0004713; F:protein tyrosine kinase activity; NAS:UniProtKB; . GO GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome; . GO GO:0048754; P:branching morphogenesis of an epithelial tube; IMP:UniProtKB; . GO GO:0008283; P:cell proliferation; TAS:ProtInc; . GO GO:0007166; P:cell surface receptor signaling pathway; NAS:UniProtKB; . GO GO:0001886; P:endothelial cell morphogenesis; IDA:UniProtKB; . GO GO:0035635; P:entry of bacterium into host cell; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0010507; P:negative regulation of autophagy; NAS:ParkinsonsUK-UCL; . GO GO:1901299; P:negative regulation of hydrogen peroxide-mediated programmed cell death; IMP:BHF-UCL; . GO GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome; . GO GO:0050918; P:positive chemotaxis; IDA:UniProtKB; . GO GO:2001028; P:positive regulation of endothelial cell chemotaxis; IMP:UniProtKB; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL; . GO GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome; . GO GO:0071526; P:semaphorin-plexin signaling pathway; IDA:UniProtKB; . GO GO:0007165; P:signal transduction; TAS:ProtInc; . Gene3D 2.130.10.10; -; 1; . Gene3D 2.60.40.10; -; 3; . InterPro IPR013783; Ig-like_fold; . InterPro IPR014756; Ig_E-set; . InterPro IPR002909; IPT; . InterPro IPR011009; Kinase-like_dom; . InterPro IPR002165; Plexin_repeat; . InterPro IPR000719; Prot_kinase_dom; . InterPro IPR017441; Protein_kinase_ATP_BS; . InterPro IPR016201; PSI; . InterPro IPR001627; Semap_dom; . InterPro IPR001245; Ser-Thr/Tyr_kinase_cat_dom; . InterPro IPR008266; Tyr_kinase_AS; . InterPro IPR020635; Tyr_kinase_cat_dom; . InterPro IPR016244; Tyr_kinase_HGF/MSP_rcpt; . InterPro IPR015943; WD40/YVTN_repeat-like_dom; . Pfam PF07714; Pkinase_Tyr; 1; . Pfam PF01437; PSI; 1; . Pfam PF01403; Sema; 1; . Pfam PF01833; TIG; 3; . PIRSF PIRSF000617; TyrPK_HGF-R; 1; . PRINTS PR00109; TYRKINASE; . SMART SM00429; IPT; 4; . SMART SM00423; PSI; 1; . SMART SM00630; Sema; 1; . SMART SM00219; TyrKc; 1; . SUPFAM SSF101912; SSF101912; 1; . SUPFAM SSF56112; SSF56112; 1; . SUPFAM SSF81296; SSF81296; 3; . PROSITE PS00107; PROTEIN_KINASE_ATP; 1; . PROSITE PS50011; PROTEIN_KINASE_DOM; 1; . PROSITE PS00109; PROTEIN_KINASE_TYR; 1; . PROSITE PS51004; SEMA; 1; .

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